234110-22-6Relevant academic research and scientific papers
Improved industrial syntheses of penciclovir and famciclovir using N2-acetyl-7-benzylguanine and a cyclic side chain precursor
Torii, Takayoshi,Yamashita, Keizo,Kojima, Mitsuhiko,Suzuki, Yumiko,Hijiya, Toyoto,Izawa, Kunisuke
, p. 625 - 634 (2008/02/08)
We have established practical synthetic methods for penciclovir (PCV, 1) and famciclovir (FCV, 2) from N2-acetyl-7-benzylguanine (NAc7BnG, 3) and 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (4)-the latter being a more easily prepared cyclic precursor
