204516-17-6Relevant academic research and scientific papers
Synthesis of 3-(trifluoromethyl)benzo[c][1,6]naphthyridines from substituted 4H-pyran-4-ones via 4-amino-5-aryl-2-(trifluoromethyl)pyridines
Tyvorskii, Vladimir I,Bobrov, Denis N,Kulinkovich, Oleg G,Aelterman, Wim,Kimpe, Norbert De
, p. 7313 - 7318 (2007/10/03)
The cyclization of acylated 4-amino-5-aryl-2-(trifluoromethyl)pyridines under the action of P2O5/POCl3 smoothly afforded 3-(trifluoromethyl)benzo[c][1,6]naphthyridines in good yields. Intermediate aminopyridines were synthesized in a two-step sequence from the corresponding 4H-pyran-4-ones, which were prepared by reaction of 2-acetyl-2-aryloxiranes and 4-dimethylamino-3-(4-methoxyphenyl)-3-buten-2-one with ethyl trifluoroacetate under basic conditions. (C) 2000 Elsevier Science Ltd.
New synthetic approaches to 2-perfluoroalkyl-4H-pyran-4-ones
Tyvorskii, Vladimir I.,Bobrov, Denis N.,Kulinkovich, Oleg G.,De Kimpe, Norbert,Tehrani, Kourosch Abbaspour
, p. 2819 - 2826 (2007/10/03)
A convenient synthesis of 5-substituted 2-perfluoroalkyl-4H-pyran-4-ones by dehydration of 2,3-dihydro-3-hydroxy-6-perfluoroalkyl-4H-pyran-4-ones is described. The 6-substituted and parent 2-perfluoroalkyl-4H-pyran-4-ones have been more successfully prepared using the condensation of alkyl enol ethers, derived from β-dicarbonyl compounds, with ethyl perfluoroalkanoates.
