20452-82-8Relevant academic research and scientific papers
Synthesis of [15N]-cholamine bromide hydrobromide
Szeto, Judy,Lemoine, Remy,Nguyen, Rosary,Olson, Lori L.,Tanga, Mary J.
, p. 391 - 394 (2018)
[15N]-Cholamine is an isotope tag for metabolomics research, because it possesses 2 important properties: an NMR active isotope and a permanent charge for MS sensitivity. Here, we present a scalable synthesis of [15N]-cholamine.
Oleanolic acid and δ - oleanolic acid derivative and medical application thereof (by machine translation)
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Paragraph 0092-0095, (2021/01/15)
The invention discloses a derivative of a pentacyclic triterpene novel AMPK agonist oleanolic acid and δ - oleanolic acid and a medical application thereof, in particular to a compound shown in formula I or formula II. A pharmaceutically acceptable salt or ester or solvate thereof, which can be used to prepare AMPK agonists with enhanced AMPK phosphorylation level activity and to the preparation of drugs for preventing or treating AMPK mediated diseases. The novel pentacyclic triterpene compound has remarkable AMPK agonist activity, and the activity is remarkably superior to the recognized AMPK agonist AICICAR, and meanwhile, the novel pentacyclic triterpene compound has pharmacokinetic properties such as better oral bioavailability and very good safety. (by machine translation)
