204577-55-9Relevant academic research and scientific papers
Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: Synthesis and biological activities of a series of 1- pyridylnaphthalene derivatives
Ukita, Tatsuzo,Sugahara, Masakatsu,Terakawa, Yoshihiro,Kuroda, Tooru,Wada, Kazuteru,Nakata, Aya,Ohmachi, Yasushi,Kikkawa, Hideo,Ikezawa, Katsuo,Naito, Kazuaki
, p. 1088 - 1099 (2007/10/03)
The structural requirements for potent and selective PDE4 inhibition were revealed in a 1-pyridylnaphthalene series, and the best compound (3kg, T-2585·HCl) was chosen for further biological evaluation (PDE4 inhibition IC50 = 0.13 nM, selectivi
A synthesis of 1-pyridylnaphthalene lignan analogs
Sugahara, Masakatsu,Moritani, Yasunori,Terakawa, Yoshihiro,Ogiku, Tsuyoshi,Ukita, Tatsuzo,Iwasaki, Tameo
, p. 1377 - 1380 (2007/10/03)
A new series of 1-arylnaphthalene lignan analogs having a variety of pyridyl substituents at the C-1 position were synthesized in moderate to good yields by means of the Diels-Alder reaction by utilizing 1-pyridylisobenzofuran precursors with dimethyl fumarate, methyl acrylate, or dimethyl acetylene dicarboxylate, followed by BF3·Et2O-mediated aromatization.
