204580-15-4

Basic information

• Product Name: 13-[3-(2-naphthyl)propanoyl]-7,10-bis(2,2,2-trichloroethoxycarbonyl)baccatin III
• Synonyms: 13-[3-(2-naphthyl)propanoyl]-7,10-bis(2,2,2-trichloroethoxycarbonyl)baccatin III
• CAS NO: 204580-15-4
• Molecular Weight: 1077.62
• Mol File: 204580-15-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 13-[3-(2-naphthyl)propanoyl]-7,10-bis(2,2,2-trichloroethoxycarbonyl)baccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 13-[3-(2-naphthyl)propanoyl]-7,10-bis(2,2,2-trichloroethoxycarbonyl)baccatin III(204580-15-4)
• EPA Substance Registry System: 13-[3-(2-naphthyl)propanoyl]-7,10-bis(2,2,2-trichloroethoxycarbonyl)baccatin III(204580-15-4)

Safety Data

• Hazardous Substances Data: 204580-15-4(Hazardous Substances Data)

Upstream product

• 21658-35-5 3-(2-naphthyl)propionic acid 
• 95603-44-4 7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III 
• 49711-14-0 (E)-3-(naphthalen-2-yl)acrylic acid 

Relevant articles and documents

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

A series of novel taxane-based multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized. Structure - activity relationship (SAR) study clearly indicates that modification of the C-7 position with hydrophobic arenecarbonylcinnamoyl groups brings about high potency against drug efflux mediated by P-glycoprotein (P-gp). Six TRAs exhibit ability to modulate a wide range of ATP-binding cassette (ABC) transporters, such as P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP), which may serve as novel broad-spectrum modulators of ABC transporters.