204582-53-6

Basic information

• Product Name: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE
• Synonyms: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE;8-BROMO-5'-O-(DMT)-N2-(DMF)-2'-DEOXYGUANOSINE;8-Bromo-5'-O-(dimethyoxytrityl)-N2-(dimethyl-aminomethylidene)-2'-deoxyguanosine
• CAS NO: 204582-53-6
• Molecular Formula: C₃₄H₃₅BrN₆O₆
• Molecular Weight: 703.58
• Mol File: 204582-53-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(204582-53-6)
• EPA Substance Registry System: 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE(204582-53-6)

Safety Data

• Hazardous Substances Data: 204582-53-6(Hazardous Substances Data)

Usage

Description

8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is a chemical compound derived from 8-Oxo-2'-deoxyguanosine (O850250), which serves as a marker for DNA damage linked to mutagenesis and carcinogenesis. 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE has the potential to induce differentiation in certain cell types, such as Friend murine erythroleukemia cells in vitro.

Uses

Used in Research Applications:
8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is used as a research tool for studying DNA damage, mutagenesis, and carcinogenesis due to its role as a marker compound indicative of these processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE is used as a potential therapeutic agent for inducing differentiation in certain types of cancer cells, such as Friend murine erythroleukemia cells.
Used in Diagnostic Applications:
8-BROMO-5'-O-(DIMETHOXYTRITYL)-N2-(DIMETHYLAMINOMETHYLIDENE)-2'-DEOXYGUANOSINE can be utilized in the development of diagnostic tools and tests to detect and monitor DNA damage associated with mutagenesis and carcinogenesis.

Upstream product

• 13389-03-2 8-bromo-2'-deoxyguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 717876-75-0 N'-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine 

Downstream Products

• 204582-55-8 N⁽²⁾-dimethylaminomethylene-8-(prop-1-ynyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine 

Relevant articles and documents

Synthesis and properties of oligonucleotides containing 8-bromo-2′-deoxyguanosine

The preparation of oligonucleotides containing 8-bromo-2′-deoxyguanosine is described. Substitution of G by 8-bromoguanine on an alternating CG decamer stabilizes the Z-form in such a way that the B-form was not observed. Melting temperatures showed that duplexes in which 8-bromo-2′-deoxyguanosine paired with natural bases were much less stable.