204589-02-6Relevant academic research and scientific papers
Anti-Pneumocystis carinii pneumonia activity of dicationic diaryl methylpyrimidines
Boykin,Kumar,Bajic,Xiao,Wilson,Bender,McCurdy,Hall,Tidwell
, p. 965 - 972 (1998)
Synthesis of 2,4-bis-(4-amidinophenyl)-6-methylpyrimidine 5, 2,4-bis-[(4-imidazolin-2-yl)phenyl]-6-methylpyrimidine 6, 2,4-bis[(4-N-i-propylamidino)phenyl]-6-methylpyrimidine 7, and 2,4-bis[(4-N-isopentylamidino)phenyl]-6-methylpyrimidine 8 starting from 4-bromobenzamidine and 4'-bromoacetophenone is reported. The synthesis of 2,4-bis-(4-amidinophenyl)-5-methylpyrimidine 12 and 2,4-bis-[(4-imidazolin-2-yl)phenyl]-5-methylpyrimidine 13, also beginning with 4-bromobenzamidine and 4'-bromopropiophenone is described. A synthesis of 4,6-bis-(4-amidinophenyl)-2-methylpyrimidine 17, 4,6-bis-[(4-imidazolin-2-yl)phenyl]-2-methylpyrimidine 18, 4,6-bis[(4-N-i-propylamidino)phenyl]-2-methylpyrimidine 19 and 4,6-bis[(4-N-n-propylamidino)phenyl]-2-methylpyrimidine 20 starting from acetamidine and 1,3-bis(4-bromophenyl)propenone is reported. Compounds 5-7 and 17-20 all bind strongly to the minor groove of poly-dA·dT whereas 8, 12 and 13 bind less tightly as judged by their ΔT(m) values. A similar trend was noted for binding of these compounds to the 12-mer-d(CGCGAATTCGCG)2. Compounds 5, 7, and 17 are more active and less toxic than pentamidine at its effective dose when evaluated against Pneumocystis carinii pneumonia (PCP) in the immunosuppressed rat model.
ELECTROCHROMIC COMPOUND, ELECTROCHROMIC COMPOSITION, DISPLAY ELEMENT, AND DIMMING ELEMENT
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Page/Page column 86-87; 95, (2015/01/16)
An electrochromic compound, represented by the following general formula (I): where X1 to X4 are each a substituent represented by the following general formula (II), an alkyl group that may contain a functional group, an aromatic hydrocarbon group that may contain a functional group, or a hydrogen atom, and at least two selected from X1 to X4 are the substituents represented by the general formula (II): where R1 to R8 are each independently a hydrogen atom, or a monovalent group that may contain a substituent; B is a substituted or unsubstituted monovalent group that may contain a functional group; A- is a monovalent anion; and m is any of 0 to 3, and R1 to R8, B, and m may each independently be different when a plurality of the substituents represented by the general formula (II) are present.
