124-42-5 Usage
Chemical Description
Acetamidine hydrochloride is an organic compound with a molecular formula C2H8ClN3.
Uses
Different sources of media describe the Uses of 124-42-5 differently. You can refer to the following data:
1. Acetamidine Hydrochloride is a compound useful in organic synthesis.
2. Acetamidine hydrochloride was used in the preparation of decarboxyectoine. It was also used in the synthesis of ethyl 4-(4-hydroxyphenyl)methylidene-2-methyl-5-oxo-1-imidazolacetate.
Chemical Properties
WHITE FINE CRYSTALLINE POWDER
General Description
Acetamidine hydrochloride is an amidine salt and its conversion to 2,4,6-trimethyl-sym-triazine has been studied.
Purification Methods
The hydrochlorde can be recrystallised from small volumes of EtOH. Alternatively it is dissolved in EtOH, filtered, Et2O is added; filter the crystalline salt off under N2 and dry it in a vacuum desiccator over H2SO4. The salt is deliquescent and should be stored in a tightly stoppered container. Its solubility in H2O is 10% at room temperature and it is soluble in Me2CO. The free base reacts strongly alkaline in H2O. It has max 224nm ( 4000) in H2O. The picrate has m 252o (sintering at ~245o). [Dox Org Synth Coll Vol I 5 1941, Davies & Parsons Chem Ind (London) 628 1958, Barnes et al. J Am Chem Soc 62 1286 1940 give m 177-178o, Beilstein 2 H 185, 2 I 85, 2 II 183, 2 III 416, 2 IV 428.]
Check Digit Verification of cas no
The CAS Registry Mumber 124-42-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 124-42:
(5*1)+(4*2)+(3*4)+(2*4)+(1*2)=35
35 % 10 = 5
So 124-42-5 is a valid CAS Registry Number.
InChI:InChI=1/C2H6N2/c1-2(3)4/h1H3,(H3,3,4)
124-42-5Relevant articles and documents
Preparation method of cefathiamidine hydrochloride
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Paragraph 0039; 0062; 0066-0068; 0072-0074; 0078-0080; ..., (2021/09/01)
The invention provides a preparation method of cefathiamidine hydrochloride. In particular, by adopting a reverse dropwise adding manner, the intermediate product vinylidene chloride is added dropwise to the ammonia methanol to generate stable cefathiamidine, and the reverse dripping mode not only effectively inhibits the decomposition of the aramidine, but also the yield of cefathiamidine hydrochloride can reach 95% or above. The method is safe to operate. The method is high in yield and low in energy consumption, and is very suitable for large-scale application.
Pyrazole derivatives
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, (2008/06/13)
This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).
