204633-46-5Relevant academic research and scientific papers
Solution-phase synthesis of 2,6,9-trisubstituted purines
Fiorini, Maria T.,Abell, Chris
, p. 1827 - 1830 (1998)
A simple three-step method for the solution-phase combinatorial synthesis of 2,6,9-trisubstituted purines from 2,6-dichloropurine is described. The synthesis exploits the use of resin capture to remove excess reagent used in the final step.
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB
Mallari, Jeremy P.,Shelat, Anang A.,Obrien, Terri,Caffrey, Conor R.,Kosinski, Aaron,Connelly, Michele,Harbut, Michael,Greenbaum, Doron,McKerrow, James H.,Guy, R. Kiplin
, p. 545 - 552 (2008/09/18)
Human African trypanosomiasis (HAT), a major health concern in sub-Saharan Africa, is caused by the protozoan parasite Trypanosoma brucei. Recent studies have shown that a cathepsin B like protease, TbcatB, is essential to the survival of T. brucei in vit
