204649-17-2Relevant academic research and scientific papers
Pyridazines, 85.1 on the regioselectivity of attack of O-nucleophiles at 4-substituted 3,6-dichloropyridazines
Heinisch, Gottfried,Matuszczak, Barbara,Wilke, Jens C.
, p. 2385 - 2393 (2007/10/03)
The influence of reaction parameters on the regioselectivity of substitution of a chloro function in 3,6-dichloro-N-methyl-N-phenylpyridazine-4-carboxamide by an alkoxy group was studied. It is shown that by choosing appropriate conditions, the attack of the nucleophile can be directed either to C-3 or C-6, thus providing convenient access to both series of alkoxychloropyridazines and their dehalogenated congeners.
