19064-64-3

Basic information

• Product Name: 3,6-Dichloro-4-methylpyridazine
• Synonyms: BUTTPARK 47\04-25;3,6-DICHLORO-4-METHYLPYRIDAZINE;4-METHYL-3,6-DICHLOROPYRIDAZINE;3,6-Dichloro-5-methylpyridazine;3,6-Dichloro-4-methylpyridazine,97%;3,6-Dichloro-4-Methyl-pyr...;3,6-Dichloro-4-Methy;3,6-Dichloro-4-methyl-1,2-diazine
• CAS NO: 19064-64-3
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163
• EINECS: 242-794-3
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridazines;PyridazinesHeterocyclic Building Blocks;pyridazine;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 19064-64-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 86-88 °C(lit.)
• Boiling Point: 149-151 °C21 mm Hg(lit.)
• Flash Point: 149-151°C/21mm
• Appearance: Brown/Crystalline Powder
• Density: 1.5462 (rough estimate)
• Vapor Pressure: 0.0104mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: -0.56±0.10(Predicted)
• BRN: 119573
• CAS DataBase Reference: 3,6-Dichloro-4-methylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-Dichloro-4-methylpyridazine(19064-64-3)
• EPA Substance Registry System: 3,6-Dichloro-4-methylpyridazine(19064-64-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36/37/39-22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 19064-64-3(Hazardous Substances Data)

Usage

Chemical Properties

Brown crystalline powder.

Uses

3,6-Dichloro-4-methylpyridazine has been used in the synthesis of 7-methyl-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid.

InChI:InChI=1/C5H4Cl2N2/c1-3-2-4(6)8-9-5(3)7/h2H,1H3

Upstream product

• 5754-18-7 4-methyl-1,2-dihydropyridazine-3,6-dione 
• 117122-49-3 methyl-maleic acid dihydrazide 
• 5754-18-7 3,6-dihydroxy-4-methylpyridazine 
• 616-02-4 citraconic acid anhydride 

Downstream Products

• 89466-36-4 3-chloro-6-methoxy-4-methylpyridazine 
• 89466-38-6 6-chloro-3-methoxy-4-methylpyridazine 
• 89943-29-3 4-Methyl-3,6-dimethoxy-pyridazin 
• 1120-88-3 4-methylpyridazine 
• 1834-27-1 6-chloro-4-methyl-2H-pyridazin-3-one 
• 1703-07-7 6-chloro-5-methyl-2H-pyridazin-3-one 
• 66346-87-0 6-chloro-5-methylpyridazin-3-amine 
• 64068-00-4 3-amino-6-chloro-4-methylpyridazine 
• 66530-56-1 (6-chloro-5-methylpyridazin-3-yl)hydrazine 
• 66530-55-0 6-chloro-3-hydrazino-4-methylpyridazine 
• 50681-26-0 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid 
• 58826-39-4 6-chloro-7-methyl[1,2,4]triazolo[4,3-b]pyridazine 
• 58826-40-7 6-chloro-8-methyl-1,2,4-triazolo[4,3-b]-pyridazine 
• 28593-26-2 6-chloro-3,7-dimethyl[1,2,4]triazolo[4,3-b]pyridazine 

Relevant articles and documents

THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF

Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.

Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors

Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]piridazines has been synthesized and characterized biologically. Structure-based optimization of the starting hit compound NNL (3) prompted us to the discovery of 4-(2-(6-methyl-[1,2,4] triazolo[4,3-b]pyridazin-8-ylamino)ethyl)phenol (12), a low nanomolar selective TNKSs inhibitor working as NAD isostere as ascertained by crystallographic analysis. Preliminary biological data candidate this new class of derivatives as a powerful pharmacological tools in the unraveling of TNKS implications in physiopathological conditions.

Preparation of substituted pyridazines

A novel process is described for preparing substituted pyridazines, where a less substituted pyridazine is reacted with a carboxylic acid in the presence of a silver ion as catalyst, using peroxydisulfate ion. The reaction is run at a temperature from about 40° to 80° C. in an aqueous solvent system and mineral acid. The substituted pyridazines are useful as intermediates to herbicidal and fungicidal compounds.