204693-60-7Relevant academic research and scientific papers
Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors
Enomoto, Hiroshi,Morikawa, Yuko,Miyake, Yurika,Tsuji, Fumio,Mizuchi, Maki,Suhara, Hiroshi,Fujimura, Ken-ichi,Horiuchi, Masato,Ban, Masakazu
scheme or table, p. 442 - 446 (2011/02/26)
We studied synthetic modifications of N-mercaptoacylamino acid derivatives to develop a new class of leukotriene A4 (LTA4) hydrolase inhibitors. S-(4-Dimethylamino)benzyl-l-cysteine derivative 2a (SA6541) showed inhibitory activity against LTA4 hydrolase (IC50, 270 nM) and selectivity over other metallopeptidases except angiotensin-converting enzyme (ACE, IC50, 520 nM). Modification at the para-substituent of the phenyl ring of compound 2a improved LTA4 hydrolase inhibitory activity as well as selectivity over ACE. Finally, we obtained S-(4-cyclohexyl)benzy-l-cysteine derivatives 11l and 16i as potent and selective LTA4 hydrolase inhibitors.
Sulfur-containing amino acid derivatives
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, (2008/06/13)
PCT No. PCT/JP97/03124 Sec. 371 Date Mar. 1, 1999 Sec. 102(e) Date Mar. 1, 1999 PCT Filed Sep. 5, 1997 PCT Pub. No. WO98/09943 PCT Pub. Date May 12, 1998A sulfur-containing amino acid compound having a high inhibitory activity on LTA4 hydrolase which is r
