20475-86-9Relevant academic research and scientific papers
Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents
Kumar, Arvind,Qayum, Arem,Sharma, Parduman Raj,Singh, Shashank Kumar,Shah, Bhahwal Ali
, p. 76 - 81 (2016)
A series of β-boswellic acid derivatives were synthesized and evaluated for anticancer activity. One of the lead analog 4f displayed significant anticancer activity against a panel of cancer cells as well as substantially inhibited colony formation in HCT
Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs
Kumar, Ajay,Shah, Bhahwal A.,Singh, Samar,Hamid, Abid,Singh, Shashank K.,Sethi, Vijay K.,Saxena, Ajit K.,Singh, Jaswant,Taneja, Subhash C.
, p. 431 - 435 (2012)
Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-κB and STAT proteins, warranting further investigations to be developed into a potential anticancer lead.
Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids
Shah, Bhahwal A.,Kumar, Ajay,Gupta, Pankaj,Sharma, Madhunika,Sethi, Vijay K.,Saxena, Ajit K.,Singh, Jaswant,Qazi, Ghulam N.,Taneja, Subhash C.
, p. 6411 - 6416 (2007)
4-Amino analogues prepared from β-boswellic acid and 11-keto-β-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.
