3877-93-8Relevant academic research and scientific papers
Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6
Sharma, Simmi,Gupta, Shilpa,Khajuria, Vidushi,Bhagat, Asha,Ahmed, Zabeer,Shah, Bhahwal Ali
supporting information, p. 695 - 698 (2016/01/09)
A library of boswellic acid analogues were synthesized and tested for their anti-inflammatory potential on key inflammatory mediators, TNF-α and IL-6. The study led to the identification of lead compounds showing significant inhibition of the cytokines, TNF-α and IL-6 both in vitro and in vivo.
Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs
Kumar, Ajay,Shah, Bhahwal A.,Singh, Samar,Hamid, Abid,Singh, Shashank K.,Sethi, Vijay K.,Saxena, Ajit K.,Singh, Jaswant,Taneja, Subhash C.
supporting information; experimental part, p. 431 - 435 (2012/03/11)
Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-κB and STAT proteins, warranting further investigations to be developed into a potential anticancer lead.
Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids
Shah, Bhahwal A.,Kumar, Ajay,Gupta, Pankaj,Sharma, Madhunika,Sethi, Vijay K.,Saxena, Ajit K.,Singh, Jaswant,Qazi, Ghulam N.,Taneja, Subhash C.
, p. 6411 - 6416 (2008/09/17)
4-Amino analogues prepared from β-boswellic acid and 11-keto-β-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.
