204764-84-1

Upstream product

• 151672-48-9 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III 
• 107-02-8 acrolein 
• 149140-53-4 C₄₂H₄₉F₅O₁₁SSi 

Downstream Products

• 204764-74-9 10-deacetoxy-10-hydroxypropyl-7-O-triethylsilylbaccatin III 
• 204991-77-5 C₆₁H₉₁NO₁₄Si₂ 
• 204764-75-0 C₄₄H₇₀O₁₀Si₂ 

Relevant academic research and scientific papers

A convenient method for the synthesis of C-10 alkylated docetaxel analogs using tris-(trimethylsilyl)silane as a radical mediator

Radical coupling has been investigated as a method for preparing Docetaxel analogs substituted at the C-10 position. C-10-Xanthate derivatives of 7-O-TES-10-deacetylbaccatin III were coupled with acrolein using organosilanes as radical mediators. Among th

Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs

An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7-O-TES-10-deacetylbaccatin III and appropriate alkenes. In addition the cytotoxic activity of 10-alkylated docetaxel analogs was evaluated. Among these analogs, a derivative having a methoxycarbonyl group at the end of the alkyl moiety exhibited more potent cytotoxic activity than docetaxel.