204852-67-5

Basic information

• Product Name: Octanoic acid, 8-[(5-chloro-2-hydroxybenzoyl)amino]-
• CAS NO: 204852-67-5
• Molecular Formula: C15H20ClNO4
• Molecular Weight: 313.781
• Mol File: 204852-67-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Octanoic acid, 8-[(5-chloro-2-hydroxybenzoyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Octanoic acid, 8-[(5-chloro-2-hydroxybenzoyl)amino]-(204852-67-5)
• EPA Substance Registry System: Octanoic acid, 8-[(5-chloro-2-hydroxybenzoyl)amino]-(204852-67-5)

Safety Data

• Hazardous Substances Data: 204852-67-5(Hazardous Substances Data)

Usage

General Description

Octanoic acid, 8-[(5-chloro-2-hydroxybenzoyl)amino]- is a chemical compound that belongs to the class of carboxylic acids. It consists of an eight-carbon chain with a terminal carboxylic acid group and a substituted benzene ring. The compound is also known as the drug clofibric acid, which has been used as a lipid-lowering agent in the treatment of hyperlipidemia. It works by inhibiting the enzyme fatty acid synthase and promoting the breakdown of fatty acids in the liver. Additionally, it has been studied for its potential anti-tumor and antiviral properties. However, its usage has declined due to concerns about its side effects, including liver toxicity and drug interactions.

Upstream product

• 1002-57-9 8-Aminooctanoic acid 
• 5538-53-4 2-acetoxy-5-chlorobenzoyl chloride 
• 287935-38-0 ethyl 8-(6-chloro-2H-1,3-benzoxazine-2,4(3H)-dionyl)octanoate 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 24088-81-1 6-chloro-benzo[e][1,3]oxazine-2,4-dione 
• 7120-43-6 5-chlorosalicylamide 

Relevant articles and documents

MANUFACTURE PROCESS OF ORGANIC COMPOUNDS

The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof and their derivatives, e.g. their salts. In particular, the present invention relates to a method of preparing (N-(5-chlorosalicyloyl)-8-aminocapryli

Use of oligosalicylates in the preparation of phenolic amido acids

A simplified methodology has been developed for preparing salicylamides from the corresponding acids via oligosalicylates which both protect the phenolic group and, at the same time, activate the carboxyl for coupling. Copyright Taylor & Francis, Inc.

Method of preparing salicylamides

The present invention provides a fast, high yield method for preparing salicylamide intermediates. The method comprises reacting a C4 or higher alkyl ester of salicylic acid or derivative thereof with at least one amine selected from the group consisting of monoalkylamines, dialkylamines, ammonia, and any combination of any of the foregoing in alcohol to yield the sali-cylamide. The C4 or higher alkyl ester of salicylic acid or a derivative thereof is preferably prepared by reacting salicylic acid or a derivative thereof with a C4 or higher alcohol in presence of at least one of sulfuric acid, a sulfonic acid, and a mineral acid. This process for preparing salicylamide intermediates from salicylic acid or derivative thereof generally has a cycle time of about 2 days, and yields about 95% of a 99% pure material. In comparison, when a C3 or lower alkyl ester is used in lieu of the C4 or higher alkyl ester, the process generally has a cycle time of 7-9 days and yields about 60% of a 95% pure material. Methods of preparing an alkylated salicylamide are also provided.