5538-53-4Relevant articles and documents
Synthesis and antioxidant activities of berberine 9-: O -benzoic acid derivatives
Liu, Yanfei,Long, Shuo,Zhang, Shanshan,Tan, Yifu,Wang, Ting,Wu, Yuwei,Jiang, Ting,Liu, Xiaoqin,Peng, Dongming,Liu, Zhenbao
, p. 17611 - 17621 (2021/05/29)
Although berberine (BBR) shows antioxidant activity, its activity is limited. We synthesized 9-O-benzoic acid berberine derivatives, and their antioxidant activities were screened via ABTS, DPPH, HOSC and FRAP assays. The para-position was modified with halogen elements on the benzoic acid ring, which led to an enhanced antioxidant activity and the substituent on the ortho-position was found to be better than the meta-position. Compounds 8p, 8c, 8d, 8i, 8j, 8l, and especially 8p showed significantly higher antioxidant activities, which could be attributed to the electronic donating groups. All the berberine derivatives possessed proper lipophilicities. In conclusion, compound 8p is a promising antioxidant candidate with remarkable elevated antioxidant activity and moderate lipophilicity.
Design, synthesis and activity evaluation of N-(pyridin-4-yl) salicylamides as antimycobacterial agents
Dian, He,Zhou, De-Bin,Mou, Jian-Ping,Yang, Zhu-Qing,Zhong, Jia,Ding, Xiao-Quan,Li, Chong,Wang, Xiao-Hong,Zhang, Jian-Gang
, p. 7269 - 7275 (2015/04/22)
A series of N-(pyridin-4-yl) salicylamides derivatives were prepared through acylation of the corresponding acetylsalicyloyl chlorides with substituted 4-amino-pyridines. These compounds were evaluated in vitro for antimycobacterial activities against Myc
Synthesis of novel thiopyrimidines: An investigation of anti-tubercular and antimicrobial activity
Haveliwala, Dhaval D.,Kamdar, Nimesh R.,Mistry, Prashant T.,Patel, Saurabh K.
experimental part, p. 451 - 462 (2012/06/30)
A variety of novel sulfur-containing tricyclic pyrimidine derivatives have been synthesized via the reaction of 2-amino-4-oxo-4H-chromene-3-carbonitriles 3(a-f) with different reagents and characterized by IR, 1H NMR, 13C NMR, mass spectrometry and elemen