204859-64-3Relevant academic research and scientific papers
54. A New Azepine-Ring Synthesis
Kvita, Vratislav,Sauter, Hanspeter,Rihs, Grety
, p. 457 - 463 (1989)
A new one-step synthesis of an azepine ring is described.The 2H-pyran-2-one ring of methyl cumalate (8) or cumalaldehyde (2) upon reaction with an 1-aminoacryl derivative, e.g. 1 or 6, is opened with subsequent decarboxylation to give a 1-aminobutadiene d
A novel synthesis of didehydroamino acid esters from azomethine ylides
Groundwater, Paul W.,Sharif, Toqir,Arany, Andrea,Hibbs, David E.,Hursthouse, Michael B.,Garnett, Ian,Nyerges, Miklos
, p. 2837 - 2846 (2007/10/03)
A novel synthesis of didehydroamino acid (DDAA) esters 5 is described, starting from aldimines 2. The mechanism for this reaction has been shown to involve the cycloaddition of an azomethine ylide 3 to an imine 2, followed by the base-catalysed ring-opening of the resulting imidazolidine intermediate 7. This novel method has also been extended to the synthesis of DDAA esters 5 catalysed by imines.
A new synthesis of didehydroamino acid esters
Groundwater, Paul W.,Sharif, Toqir,Arany, Andrea,Hibbs, David E.,Hursthouse, Michael B.,Nyerges, Miklos
, p. 1433 - 1436 (2007/10/03)
A novel synthesis of didehydroamino acid (DDAA) esters 4 is described, starting from aldimines 1. The mechanism for this reaction involves the cycloaddition of an azomethine ylide 2 to an imine 1, followed by the base-catalysed ring-opening of the imidazolidine intermediate 6. This method has also been extended to the synthesis of DDAA esters 4h-j catalysed by an imine 1a.
