204860-59-3

Upstream product

• 84538-44-3 4-cyanomethyl-2,6-dimethoxy-5-nitropyrimidine 
• 204860-46-8 6-(2-cyano-1,3-diphenylprop-2-yl)-2,4-dimethoxy-5-nitropyrimidine 
• 204714-48-7 7,7-Dibenzyl-2,4-dimethoxy-7H-pyrrolo[3,2-d]pyrimidin-6-ylamine 
• 100-39-0 benzyl bromide 
• 204860-57-1 7-Benzyl-2,4-dimethoxy-5H-pyrrolo[3,2-d]pyrimidin-6-ylamine 
• 204860-51-5 5-amino-6-(2-cyano-1,3-diphenylprop-2-yl)-2,4-dimethoxypyrimidine 

Relevant academic research and scientific papers

Catalytic hydrogenation causes C-benzyl bond cleavage in 6-amino-7,7-dibenzyl-2,4-dimethoxy-7H-pyrrolo[3,2-d]pyrimidine: An example indicating novel route to 6-amino-7-benzyl-5H-pyrrolo-[3,2-d]pyrimidines and related compounds

7-Benzyl-2,4-dimethoxy-5H-pyrrolo[3,2-d]pyrimidine (8) and 6-amino-7,7-dibenzyl-2,4-dimethoxy-7H-pyrrolo[3,2-d]pyrimidine (10) were prepared by reductive cyclization of the corresponding 6-(1-cyanoalkyl)-5-nitropyrimidines. Catalytic hydrogenation of compound 10 causes a C-C bond cleavage between carbon C-7 and one of the geminal benzyl groups. It leads to the formation of 6-amino-7-benzyl-2,4-dimethoxy-5H-pyrrolo[3,2-d]pyrimidine (12) which was spontaneously oxidized by air to 6-amino-7-benzyl-2,4-dimethoxy-7-hydroxy-7H-pyrrolo[3,2-d]pyrimidine (13).