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204863-52-5

ethyl 4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 204863-52-5 Structure

  • Basic information

    1. Product Name: ethyl 4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoate
    2. Synonyms: ethyl 4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoate
    3. CAS NO:204863-52-5
    4. Molecular Formula:
    5. Molecular Weight: 313.331
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 204863-52-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoate(204863-52-5)
    11. EPA Substance Registry System: ethyl 4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoate(204863-52-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 204863-52-5(Hazardous Substances Data)

204863-52-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 204863-52-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,8,6 and 3 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 204863-52:
(8*2)+(7*0)+(6*4)+(5*8)+(4*6)+(3*3)+(2*5)+(1*2)=125
125 % 10 = 5
So 204863-52-5 is a valid CAS Registry Number.

204863-52-5Relevant articles and documents

Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6-phosphogluconolactonase Inhibitor (R,Z)-N-((1-Ethylpyrrolidin-2-yl)methyl)-2- (2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro

Preuss, Janina,Malone, Patrick,Peddibhotla, Satyamaheshwar,Hedrick, Michael P.,Hershberger, Paul,Gosalia, Palak,Milewski, Monika,Li, Yujie Linda,Sugarman, Eliot,Hood, Becky,Suyama, Eigo,Nguyen, Kevin,Vasile, Stefan,Sergienko, Eduard,Mangravita-Novo, Arianna,Vicchiarelli, Michael,McAnally, Danielle,Smith, Layton H,Roth, Gregory P.,Diwan, Jena,Chung, Thomas D.Y.,Jortzik, Esther,Rahlfs, Stefan,Becker, Katja,Pinkerton, Anthony B.,Bode, Lars

supporting information, p. 7262 - 7272 (2012/11/07)

A high-throughput screen of the NIH's MLSMR collection of ～340000 compounds was undertaken to identify compounds that inhibit Plasmodium falciparum glucose-6-phosphate dehydrogenase (Pf G6PD). PfG6PD is important for proliferating and propagating P. falciparum and differs structurally and mechanistically from the human orthologue. The reaction catalyzed by glucose-6-phosphate dehydrogenase (G6PD) is the first, rate-limiting step in the pentose phosphate pathway (PPP), a key metabolic pathway sustaining anabolic needs in reductive equivalents and synthetic materials in fast-growing cells. In P. falciparum, the bifunctional enzyme glucose-6-phosphate dehydrogenase-6- phosphogluconolactonase (Pf GluPho) catalyzes the first two steps of the PPP. Because P. falciparum and infected host red blood cells rely on accelerated glucose flux, they depend on the G6PD activity of PfGluPho. The lead compound identified from this effort, (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2- fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carbox-amide, 11 (ML276), is a submicromolar inhibitor of PfG6PD (IC50 = 889 nM). It is completely selective for the enzyme's human isoform, displays micromolar potency (IC50 = 2.6 μM) against P. falciparum in culture, and has good drug-like properties, including high solubility and moderate microsomal stability. Studies testing the potential advantage of inhibiting Pf G6PD in vivo are in progress.

AMINE COMPOUNDS

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Page 211-212, (2010/02/07)

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.

Quantitative structure-activity relationship study of N-(3-oxo-3,4- dihydro-2H-benzol[1,4]thiazine-6-carbonyl)guanidines as potent na/h exchange inhibitors

Yamamoto, Takeshi,Hori, Manabu,Watanabe, Ikuo,Harada, Kengo,Ikeda, Shoji,Ohtaka, Hiroshi

, p. 843 - 849 (2007/10/03)

We have previously reported that N-(4-isopropyl-2,2-dimethyl-3-oxo-3,4- dihydro-2H-benzo[1,4]oxazine-6carbonyl)guanidine (4b) methanesulfonate salt (KB-R9032) is a potent and highly water-soluble Na/H exchange inhibitor. In a series of studies on Na/H exc

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