2049-12-9

Basic information

• Product Name: 5,5-dimethyl-2-phenyl-1,3-dioxolan-4-one
• Synonyms: 5,5-dimethyl-2-phenyl-1,3-dioxolan-4-one
• CAS NO: 2049-12-9
• Molecular Weight: 192.214
• Mol File: 2049-12-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,5-dimethyl-2-phenyl-1,3-dioxolan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-dimethyl-2-phenyl-1,3-dioxolan-4-one(2049-12-9)
• EPA Substance Registry System: 5,5-dimethyl-2-phenyl-1,3-dioxolan-4-one(2049-12-9)

Safety Data

• Hazardous Substances Data: 2049-12-9(Hazardous Substances Data)

Upstream product

• 594-61-6 2-methyllactic acid 
• 100-52-7 benzaldehyde 

Downstream Products

• 22940-38-1 4,4-dimethyl-5-methylene-2-phenyl-1,3-dioxolane 

Relevant articles and documents

Total syntheses of ent-heliespirones A and C

Stereodivergent total syntheses of ent-heliespirone A and C were both completed in 11 vessels and ～24% combined overall yield (A + C). These syntheses employed an identical inverse demand Diels-Alder reaction between a surrogate for an extendedly conjugated γ-δ unsaturated ortho-quinone methide and l-lactic-acid-derived exocyclic enol ether. Novel reactions of special note include a diastereoselective reduction of a chroman spiroketal by combination of borontrifluoride etherate and triethyl silane, along with oxidative rupture of a chroman etherial ring into the corresponding p-quinone by argentic oxide (AgO). In addition, an unusual intramolecular etherification of a 3° alcohol caused by cerium ammonium nitrate was observed.