204914-85-2

Upstream product

• 113400-36-5 benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate 
• 870-63-3 prenyl bromide 

Downstream Products

• 204914-99-8 (2S,4S)-1-{(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-methoxycarbonylmethyl-pyrrolidine-2-carbonyl]-4-methoxycarbonylmethyl-pyrrolidine-2-carbonyl}-4-methoxycarbonylmethyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 204914-93-2 (2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-methoxycarbonylmethyl-pyrrolidine-2-carbonyl]-4-methoxycarbonylmethyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 204914-90-9 (2S,4S)-4-Methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 204915-18-4 (2S,4S)-1-(2,2-Dimethyl-propionyl)-4-methoxycarbonylmethyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 204914-89-6 (2S,4S)-4-(2-Oxo-ethyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 204914-87-4 (2S,4R)-4-(3-Methyl-but-2-enyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 

Relevant academic research and scientific papers

LINCOMYCIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Pseudo-A(1,3) strain as a key conformational control element in the design of poly-L-proline type II peptide mimics

A strategy for the synthesis of peptide mimics of the poly-L-proline type II secondary structure from 4-substituted prolines is presented. Dimeric and trimeric oligomers composed of 4-substituted prolines are shown by NMR to preferentially populate the poly-L-proline type II secondary structure in both CDCl3 and D2O. Oligomers composed of 4-substituted prolines thus imitate the desired backbone conformation and are able to incorporate non- prolyl side chains on the proline backbone.