204914-93-2

Upstream product

• 204914-85-2 (2S,4R)-4-(3-Methyl-but-2-enyl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 204914-90-9 (2S,4S)-4-Methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 204915-18-4 (2S,4S)-1-(2,2-Dimethyl-propionyl)-4-methoxycarbonylmethyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 204914-87-4 (2S,4R)-4-(3-Methyl-but-2-enyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 204914-89-6 (2S,4S)-4-(2-Oxo-ethyl)-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 113400-36-5 benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate 
• 204914-92-1 (2S,4S)-1-(2,2-Dimethyl-propionyl)-4-methoxycarbonylmethyl-pyrrolidine-2-carboxylic acid 

Downstream Products

• 204914-99-8 (2S,4S)-1-{(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-methoxycarbonylmethyl-pyrrolidine-2-carbonyl]-4-methoxycarbonylmethyl-pyrrolidine-2-carbonyl}-4-methoxycarbonylmethyl-pyrrolidine-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Pseudo-A(1,3) strain as a key conformational control element in the design of poly-L-proline type II peptide mimics

A strategy for the synthesis of peptide mimics of the poly-L-proline type II secondary structure from 4-substituted prolines is presented. Dimeric and trimeric oligomers composed of 4-substituted prolines are shown by NMR to preferentially populate the poly-L-proline type II secondary structure in both CDCl3 and D2O. Oligomers composed of 4-substituted prolines thus imitate the desired backbone conformation and are able to incorporate non- prolyl side chains on the proline backbone.