204916-45-0

Basic information

• Product Name: 4-(4-Bromo-butyl)-2-phenyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
• Synonyms: 4-(4-Bromo-butyl)-2-phenyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
• CAS NO: 204916-45-0
• Molecular Weight: 361.238
• Mol File: 204916-45-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-Bromo-butyl)-2-phenyl-4H-pyrido[3,2-b][1,4]oxazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Bromo-butyl)-2-phenyl-4H-pyrido[3,2-b][1,4]oxazin-3-one(204916-45-0)
• EPA Substance Registry System: 4-(4-Bromo-butyl)-2-phenyl-4H-pyrido[3,2-b][1,4]oxazin-3-one(204916-45-0)

Safety Data

• Hazardous Substances Data: 204916-45-0(Hazardous Substances Data)

Upstream product

• 2912-62-1 α-chlorophenylacetyl chloride 
• 16867-03-1 2-amino-3-hydroxypyridine 
• 110-52-1 1,4-dibromo-butane 
• 24675-93-2 2-phenyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 

Relevant articles and documents

Substituted pyrido[3,2-b]oxazin-3(4H)-ones: Synthesis and evaluation of antinociceptive activity

A new series of N-substituted pyrido[3,2-b]oxazinones has been synthesized, pharmacologically evaluated, and compared with acetyl salicylic acid. The compound with the maximal combination of safety and analgesic efficacy was 4-{3-[4-(4-fluorophenyl-1-piperazinyl)propyl]}- 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one (6c) with ED50 values of 12.5 mg/kg po (mouse: phenylquinone writhing test) and 27.8 mg/kg po (rat: acetic acid writhing test), respectively. Compound 6c proved to be more active than aspirin with a safety index of 5.1.