24675-93-2

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 2912-62-1 α-chlorophenylacetyl chloride 

Downstream Products

• 34950-63-5 4-methyl-2-phenyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 
• 24733-08-2 2-phenyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine 
• 204916-45-0 4-(4-Bromo-butyl)-2-phenyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 

Relevant academic research and scientific papers

Substituted pyrido[3,2-b]oxazin-3(4H)-ones: Synthesis and evaluation of antinociceptive activity

A new series of N-substituted pyrido[3,2-b]oxazinones has been synthesized, pharmacologically evaluated, and compared with acetyl salicylic acid. The compound with the maximal combination of safety and analgesic efficacy was 4-{3-[4-(4-fluorophenyl-1-piperazinyl)propyl]}- 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one (6c) with ED50 values of 12.5 mg/kg po (mouse: phenylquinone writhing test) and 27.8 mg/kg po (rat: acetic acid writhing test), respectively. Compound 6c proved to be more active than aspirin with a safety index of 5.1.