204918-67-2Relevant academic research and scientific papers
Arabinofuranosyl oligosaccharides from mycobacteria: Synthesis and effect of glycosylation on ring conformation and hydroxymethyl group rotamer populations
D'Souza, Francis W.,Ayers, Joseph D.,McCarren, Patrick R.,Lowary, Todd L.
, p. 1251 - 1260 (2007/10/03)
A series of αD-arabinofuranosyl oligosaccharides (2-8) that are fragments of the arabinan portions of two polysaccharides present in the cell wall of Mycobacterium tuberculosis have been synthesized. Preparation of the oligosaccharides involved the sequen
Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates
Ayers, Joseph D.,Lowary, Todd L.,Morehouse, Caroline B.,Besra, Gurdyal S.
, p. 437 - 442 (2007/10/03)
A series of arabinofuranosyl oligosaccharides found as constituent parts of the polysaccharide portion of the cell wall of Mycobacterium tuberculosis have been chemically synthesized. Screening of these oligosaccharidss as substrates for arabinosyltransferases present in mycobacterial membrane preparations suggests that modified oligosaccharide analogs as small as disaccharides may be inhibitors of glycan biosynthesis. Such inhibitors would be of potential utility as lead compounds in the identification of new drugs for the treatment of mycobacterial infections.
