204977-88-8

Basic information

• Product Name: Pyridine, 2-(2-methoxyethoxy)- (9CI)
• Synonyms: Pyridine, 2-(2-methoxyethoxy)- (9CI)
• CAS NO: 204977-88-8
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.17844
• Product Categories: METHOXY
• Mol File: 204977-88-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 2-(2-methoxyethoxy)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(2-methoxyethoxy)- (9CI)(204977-88-8)
• EPA Substance Registry System: Pyridine, 2-(2-methoxyethoxy)- (9CI)(204977-88-8)

Safety Data

• Hazardous Substances Data: 204977-88-8(Hazardous Substances Data)

Upstream product

• 110-71-4 1,2-dimethoxyethane 
• 107263-95-6 N-fluoropyridinium triflate 
• 15925-47-0 S-tert-butyl acetothioacetate 

Relevant articles and documents

A general synthesis of quinoline-2,5,8(1H)-triones via acylation of 2,5- dimethoxyaniline with S-tert-butyl thioacetates by application of the Knorr cyclization

An efficient synthesis of quinoline-2,5,8(1H)-triones bearing alkyl groups at C3 and/or C4 is described. The reaction sequence employed involves Knorr cyclization of 2,5-dimethoxyanilides into 5,8- dimethoxyquinoline systems, followed by oxidative demethylation with cerium ammonium nitrate. The starting 2,5-dimethoxyanilides were prepared by chemoselective acylation of 2,5-dimethoxyaniline with a series of β-oxo thioesters obtained by regioselective alkylation of S-tert-butyl acetothioacetate (1) at C2 and/or C4. The introduction of electrophiles other than alkyl groups at C2 on 1 was also studied.