204980-34-7Relevant academic research and scientific papers
Hydride reduction of NAD+ analogues by isopropyl alcohol: kinetics, deuterium isotope effects and mechanism
Lu, Yun,Qu, Fengrui,Moore, Brian,Endicott, Donald,Kuester, William
, p. 4763 - 4770 (2008)
(Chemical Equation Presented) Observed pseudo-first-order rate constants (kobs) of the hydride-transfer reactions from isopropyl alcohol (i-PrOH) to two NAD+ analogues, 9-phenylxanthylium ion (PhXn +) and 10-methylacridini
Room-Temperature Palladium-Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals
Ou, Wei,Xiang, Xudong,Zou, Ru,Xu, Qing,Loh, Kian Ping,Su, Chenliang
supporting information, p. 6357 - 6361 (2021/02/16)
Site-specific incorporation of deuterium into drug molecules to study and improve their biological properties is crucial for drug discovery and development. Herein, we describe a palladium-catalyzed room-temperature deuterogenolysis of carbon–oxygen bonds
Method for constructing carbon-hydrogen bond by catalyzing alcohol dehydroxylation with palladium/platinum
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Paragraph 0114-0116; 0118, (2019/12/25)
The invention discloses a method for constructing a carbon-hydrogen (deuterium) bond. The method comprises the following step: in the presence of a palladium/platinum catalyst and aryl halide, an alcohol hydroxyl group of an alcohol and hydrogen (deuterium) gas is replaced by hydrogen (deuterium) to construct the carbon-hydrogen (deuterium) bond. According to the method, the palladium/platinum catalyst is used as a catalyst, the green hydrogen (deuterium) gas is used as a hydrogen (deuterium) source, efficient alcohol dehydroxylation is performed at room temperature to construct the carbon-hydrogen (deuterium) bond, and the method is particularly suitable for constructing the carbon-deuterium bond and can be widely applied to synthesis of deuterated drugs.
