205-45-8

Basic information

• Product Name: 7H-pyrido[3,2-c]carbazole
• Synonyms: 7H-Pyrido(3,2-c)carbazole
• CAS NO: 205-45-8
• Molecular Formula: C₁₅H₁₀N₂
• Molecular Weight: 218.2533
• Mol File: 205-45-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 173-174 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 472.2°C at 760 mmHg
• Flash Point: 219.7°C
• Density: 1.336g/cm³
• Vapor Pressure: 1.25E-08mmHg at 25°C
• Refractive Index: 1.839
• PKA: 15.44±0.30(Predicted)
• CAS DataBase Reference: 7H-pyrido[3,2-c]carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-pyrido[3,2-c]carbazole(205-45-8)
• EPA Substance Registry System: 7H-pyrido[3,2-c]carbazole(205-45-8)

Safety Data

• Hazardous Substances Data: 205-45-8(Hazardous Substances Data)

Upstream product

• 64-19-7 acetic acid 
• 16567-18-3 8-bromoquinoline 

Relevant articles and documents

Mapping the reactivity of the quinoline ring-system – Synthesis of the tetracyclic ring-system of isocryptolepine and regioisomers

Bromoquinolines (2-bromoquinoline – 8-bromoquinoline and 5-bromo-3-methoxyquinoline) and 2-aminophenylboronic acid hydrochloride were subjected to Suzuki-Miyaura cross-coupling conditions resulting in formation of the desired biaryl systems in good yields. The resulting biaryls were then subjected to palladium catalyzed C–H activation/C–N bond formation utilizing PdCl2(dppf). The reactions revealed large differences in reactivity depending on the attachment point for the 2-aminophenyl group on the quinoline. The variation in the reactivity was rationalized based on the electron distribution around the quinoline ring-system.