205037-64-5

Basic information

• Product Name: N-(4-Chlorobenzyl)-8-hydroxyquinoline-7-carboxamide
• Synonyms: PNU-142796
• CAS NO: 205037-64-5
• Molecular Formula: C₁₇H₁₃ClN₂O₂
• Molecular Weight: 312.75836
• Mol File: 205037-64-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(4-Chlorobenzyl)-8-hydroxyquinoline-7-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Chlorobenzyl)-8-hydroxyquinoline-7-carboxamide(205037-64-5)
• EPA Substance Registry System: N-(4-Chlorobenzyl)-8-hydroxyquinoline-7-carboxamide(205037-64-5)

Safety Data

• Hazardous Substances Data: 205037-64-5(Hazardous Substances Data)

Upstream product

• 104-86-9 4-chlorobenzylamine 
• 19829-79-9 8-hydroxy-7-quinolinecarboxylic acid 

Relevant articles and documents

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1α prolyl hydroxylase inhibitors

A new series of potent 8-hydroxyquinolines was designed based on the newly resolved X-ray crystal structure of EGLN-1. Both alkyl and aryl 8-hydroxyquinoline-7-carboxyamides were good HIF-1α prolyl hydroxylase (EGLN) inhibitors. In subsequent VEGF inducti

SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS

The present invention provides secondary 8-hydroxyquinoiine-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulahopsis Brevicaulis. These compounds are active against Candida species such as Candida Albicans and Candida Glabrata.

8-hydroxy-7-substituted quinolines as anti-viral agents

The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula III These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus and the human herpes virus type 8 (HHV-8).