205115-99-7

Upstream product

• 100-52-7 benzaldehyde 
• 144978-12-1 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate 
• 4720-29-0 3-(benzylamino)propan-1-ol 
• 205115-96-4 Benzyl-(4,4-dibromo-but-3-enyl)-carbamic acid tert-butyl ester 
• 98014-76-7 3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propan-1-ol 
• 98014-77-8 3-(N-benzyl-N-tert-butoxycarbonylamino)propanal 
• 205115-97-5 5-Benzylamino-pent-2-ynoic acid methyl ester 
• 205115-94-2 (R)-4-Ethylsulfanylcarbonyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 

Downstream Products

• 205116-01-4 (3R,5R,10S)-7-Benzyl-10-methoxycarbonylmethyl-1,6-dioxo-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester 
• 205116-02-5 (3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(pyridin-2-ylsulfanylcarbonylmethyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester 
• 205116-03-6 (3R,5R,10S)-7-Benzyl-1,6-dioxo-10-(2-oxo-hexyl)-2,7-diaza-spiro[4.5]decane-2,3-dicarboxylic acid 2-tert-butyl ester 3-ethyl ester 

Relevant academic research and scientific papers

An efficient and stereoselective construction of the core structure of the manzamines via an intramolecular Michael reaction

A strategically functionalized tricyclic subunit of the manzamines was efficiently synthesized with complete stereochemical control using a combination of an intramolecular Michael reaction of a pyroglutamic acid derivative and a hydrogenation.