205180-76-3

Upstream product

• 205180-64-9 2-(2-Ethoxycarbonylmethoxy-phenoxymethyl)-thiazole-4-carboxylic acid ethyl ester 
• 205180-60-5 1,2-bis(thioamidomethyloxy)benzene 
• 120-80-9 benzene-1,2-diol 
• 82002-59-3 o-phenylenedioxydi-acetic acid diamide 
• 205180-74-1 2-[2-(4-Hydroxymethyl-thiazol-2-ylmethoxy)-phenoxy]-ethanol 

Relevant academic research and scientific papers

Synthesis of Thiazole-containing Benzo-crown Ethers

A series of benzo-crown ethers containing the thiazole subcyclic moity have been synthesized. Reaction of 1,2-bis(thioamidomethyloxy)benzene 2 with ethyl bromopyruvate in ethanol provided 1,2-bis(thiazolyl)benzene 4 (80%) along with thiazole 5 (14%). Reduction of 4 with lithium aluminum hydride followed by mesylation-bromination gave 7. Similar treatment of 5 with lithium aluminum hydride followed by bromination resulted in 12. Benzo-crown ethers 8,9,10, and 13 were prepared from the reactions of 4-bromomethylthiazole derivatives 7 and 12 with catechol and resorcinol derivatives in the presence of potassium hydride.