82002-59-3

Upstream product

• 5411-14-3 2-[2-(2-hydroxy-2-oxoethoxy)phenoxy]acetic acid 
• 144-48-9 iodacetamide 
• 120-80-9 benzene-1,2-diol 
• 79-07-2 Chloroacetamide 

Downstream Products

• 519183-15-4 2-Carbamoylmethoxy-4-chlorosulfonylphenoxyacetamide 
• 205180-62-7 1,2-bis[2'(4'-carbetoxy)thiazolyl]methyloxybenzene 
• 205180-64-9 2-(2-Ethoxycarbonylmethoxy-phenoxymethyl)-thiazole-4-carboxylic acid ethyl ester 
• 205180-67-2 1,2-bis[2'(4'-bromomethyl)thiazolyl]methyloxybenzene 
• 205180-65-0 {2-[2-(4-Hydroxymethyl-thiazol-2-ylmethoxy)-phenoxymethyl]-thiazol-4-yl}-methanol 
• 205180-76-3 2-[2-(2-Bromo-ethoxy)-phenoxymethyl]-4-bromomethyl-thiazole 
• 205180-74-1 2-[2-(4-Hydroxymethyl-thiazol-2-ylmethoxy)-phenoxy]-ethanol 
• 205180-60-5 1,2-bis(thioamidomethyloxy)benzene 

Relevant academic research and scientific papers

Process for preparing isomerically pure prodrugs of proton pump inhibitors

Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.

Synthesis of Thiazole-containing Benzo-crown Ethers

A series of benzo-crown ethers containing the thiazole subcyclic moity have been synthesized. Reaction of 1,2-bis(thioamidomethyloxy)benzene 2 with ethyl bromopyruvate in ethanol provided 1,2-bis(thiazolyl)benzene 4 (80%) along with thiazole 5 (14%). Reduction of 4 with lithium aluminum hydride followed by mesylation-bromination gave 7. Similar treatment of 5 with lithium aluminum hydride followed by bromination resulted in 12. Benzo-crown ethers 8,9,10, and 13 were prepared from the reactions of 4-bromomethylthiazole derivatives 7 and 12 with catechol and resorcinol derivatives in the presence of potassium hydride.

Neutral Diamide Ionophores - Phenylenedioxydiacetamides

The preparation of a series of neutral ligands containing ether and amide groups is described.These ligands as well as related ones bearing other diamide groups are shown to selectively chelate Group IIA cations by picrate extraction from water to methylene dichloride.This result was also confirmed by atomic absorption measurement.The changes in UV absorption of aromatic rings and amide groups in the ligands upon titration with metal salts in methanol allow the estimation of the ordering of cation binding. - Keywords: Acyclic ionophores; Neutral ionophores; Phenylenedioxydiacetamide, complexation studies