205187-05-9

Basic information

• Product Name: 3-fluorophenyl N,N-diethyl-O-carbamate
• Synonyms: 3-fluorophenyl N,N-diethyl-O-carbamate
• CAS NO: 205187-05-9
• Molecular Weight: 211.236
• Mol File: 205187-05-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-fluorophenyl N,N-diethyl-O-carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluorophenyl N,N-diethyl-O-carbamate(205187-05-9)
• EPA Substance Registry System: 3-fluorophenyl N,N-diethyl-O-carbamate(205187-05-9)

Safety Data

• Hazardous Substances Data: 205187-05-9(Hazardous Substances Data)

Upstream product

• 372-20-3 3-fluorophenol 
• 88-10-8 N,N-diethylcarbamyl chloride 

Downstream Products

• 372-20-3 3-fluorophenol 
• 863870-89-7 4-fluoro-2-phenylbenzo[b]furan 

Relevant articles and documents

Experimental and computational study of the 1,5-o → n carbamoyl snieckus-fries-type rearrangement

The reactions of o-lithiated O-aryl N,N-diethylcarbamates with different C-N multiple bond electrophiles have been thoroughly studied. A 1,5-O → N carbamoyl shift, a new variation of the anionic Fries-type rearrangement, takes place when nitriles, imines, or alkylcarbodiimides are employed. In these cases, the carbamoyl group plays a dual role as a directing group, building up a variety of functional groups through the 1,5-O → N carbamoyl migration. On the other hand, the use of iso(thio)cyanates and arylcarbodiimides led to non-rearranged o-functionalized Oarylcarbamates. This reactivity was further computationally explored, and the governing factor could be traced back to the relative basicity of the alternative products (migrated vs nonmigrated substrates). This exploration also provided interesting insights about the degree of complexation of the lithium cations onto these substrates. A new access to useful 2-hydroxybenzophenone derivatives has also been developed.

KINASE INHIBITOR

[Problem] To provide a novel PIM-3 inhibitor and a novel cancer therapeutic drug, in particular, a therapeutic drug for pancreatic cancer. [Solution] A PIM-3 kinase inhibitor comprising a compound represented by general formula (I) or a pharmacologically acceptable salt, hydrate or solvate thereof.

A new and efficient synthesis of 4-functionalized benzo[6]furans from 2,3-dihalophenols

Tandem Sonogashira coupling/5-endo-dig cyclization reactions on 2,3-dihalophenols suppose a straightforward entry to 4-halobenzo[b]furans, which can be easily transformed into 4-functionalized benzo[b]furans, that are difficult to synthesize by other proc