205236-92-6Relevant articles and documents
Potent dipeptide inhibitors of the pp60(c-src) SH2 domain
Pacofsky, Gregory J.,Lackey, Karen,Alligood, Krystal J.,Berman, Judd,Charifson, Paul S.,Crosby, Renae M.,Dorsey Jr., George F.,Feldman, Paul L.,Gilmer, Tona M.,Hummel, Conrad W.,Jordan, Steven R.,Mohr, Christopher,Shewchuk, Lisa M.,Sternbach, Daniel D.,Rodriguez, Marc
, p. 1894 - 1908 (2007/10/03)
The design, synthesis, and evaluation of dipeptide analogues as ligands for the pp60(c-src) SH2 domain are described. The critical binding interactions between Ac-Tyr-Glu-N(n-C5H11)2 (2) and the protein are established and