20529-20-8

Upstream product

• 48167-19-7 3-[4-(3-chlorophenyl)-piperazin-1-yl]-propionitrile 
• 25557-35-1 2-(3-(4-(3-chlorophenyl)-piperazin-1-yl)-propyl)-isoindoline-1,3-dione 
• 6640-24-0 N-(m-chlorophenyl)piperazine 

Downstream Products

• 90619-46-8 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-1,8,8-trimethyl-3-aza-bicyclo[3.2.1]octane-2,4-dione; hydrochloride 
• 891879-64-4 E₂₁₃-1628 
• 1044529-27-2 Z₀₆₆-0126 
• 1155401-98-1 N-[3-{4-(3-chlorophenyl)-piperazin-1-yl}-propyl]-3-(2-trifluoromethylphenyl)-pyrrolidine-2,5-dione hydrochloride 
• 1155401-88-9 N-[3-{4-(3-chlorophenyl)-piperazin-1-yl}-propyl]-3-(2-methylphenyl)-pyrrolidine-2,5-dione hydrochloride 
• 923229-35-0 7-methyl-8-[3-(N₄-3'-chlorophenyl)-piperazin-N₁-yl-propyl]-1,3-dimethyl-(1H,8H)-imidazo[2,1-f]purine-2,4-dione 
• 79323-06-1 1-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-4-(4-methoxy-phenyl)-piperidine-2,6-dione 

Relevant academic research and scientific papers

Small-Molecule Inhibition of the UNC119–Cargo Interaction

N-Terminal myristoylation facilitates membrane binding and activity of proteins, in particular of Src family kinases, but the underlying mechanisms are only beginning to be understood. The chaperones UNC119A/B regulate the cellular distribution and signal

Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Arylpiperzine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated as novel antidepressant compounds. The various analogues were efficiently prepared and bio-assayed for binding to 5-HT2A, 5-HT2C receptor, and

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs

2-AMINOPYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN URINARY THERAPEUTICS

A compound of formula (I) STR1 in which n denotes 2, 3, 4, or 5, p denotes 0 or 1,m denotes 0, 1, 2, 3, 4, or 5, and R 1 denotes a hydrogen atom or a methyl group,each X, which may be identical or different to any other X if m is greater than 1, denotes fluorine, chlorine, methoxy, isopropyl or cyclopropyl,in the form of a free base or an acid addition salt.

POTENTIAL NEUROLEPTICS OF THE ORTHOPRAMIDE SERIES; SYNTHESIS OF N-(3-(TERT.AMINO)PROPYL)-5-SULFAMOYL-2-METHOXYBENZAMIDES

Heating ethyl 5-sulfamoyl-2-methoxybenzoate with a series of twelve 3-(tert.amino)propylamines (IIIa-IIIl) afforded the title compounds IIa-IIl which were transformed to salts and subjected to pharmacological screening as potential neuroleptics of the sulpiride series.Only compounds IId (hydrogen oxalate, VUFB-15 453) and IIg (methanesulfonate, VUFB-15 397) showed indications of the desired psychotropic activity.