205312-69-2Relevant academic research and scientific papers
Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC
Boike, Lydia,Cioffi, Alexander G.,Majewski, Felix C.,Co, Jennifer,Henning, Nathaniel J.,Jones, Michael D.,Liu, Gang,McKenna, Jeffrey M.,Tallarico, John A.,Schirle, Markus,Nomura, Daniel K.
, p. 4 - 17,13 (2020/10/12)
MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered. Here, we have performed a cysteine-reactive covalent ligand screen to identify compoun
HETEROCYCLIC COMPOUNDS AND USES THEREOF
-
Page/Page column 51-52, (2009/01/20)
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
