205313-15-1

Basic information

• Product Name: [1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-{3-[(E)-2-(5-trifluoromethyl-pyridin-2-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid methyl ester
• CAS NO: 205313-15-1
• Molecular Weight: 583.715
• Mol File: 205313-15-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-{3-[(E)-2-(5-trifluoromethyl-pyridin-2-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-{3-[(E)-2-(5-trifluoromethyl-pyridin-2-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid methyl ester(205313-15-1)
• EPA Substance Registry System: [1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-{3-[(E)-2-(5-trifluoromethyl-pyridin-2-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid methyl ester(205313-15-1)

Safety Data

• Hazardous Substances Data: 205313-15-1(Hazardous Substances Data)

Upstream product

• 128790-14-7 5-trifluoromethyl-pyridin-2-ylmethyl chloride 
• 153494-26-9 Methyl 1-(((1 (R)-(3-formylphenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetate 
• 31181-54-1 2-Methyl-5-(trifluoromethyl)pyridine 

Relevant articles and documents

A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singular) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L-733,321) as an optimized candidate.