31181-54-1

Basic information

• Product Name: 2-METHYL-5-(TRIFLUOROMETHYL)PYRIDINE
• Synonyms: 2-METHYL-5-(TRIFLUOROMETHYL)PYRIDINE;2-Methyl-5-(trifluoromethyl)pyridin
• CAS NO: 31181-54-1
• Molecular Formula: C7H6F3N
• Molecular Weight: 161.1244496
• Mol File: 31181-54-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 144℃
• Flash Point: 41℃
• Appearance: /
• Density: 1.216
• Vapor Pressure: 6.44mmHg at 25°C
• Refractive Index: 1.429
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.53±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-5-(TRIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-5-(TRIFLUOROMETHYL)PYRIDINE(31181-54-1)
• EPA Substance Registry System: 2-METHYL-5-(TRIFLUOROMETHYL)PYRIDINE(31181-54-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 31181-54-1(Hazardous Substances Data)

Usage

General Description

2-Methyl-5-(trifluoromethyl)pyridine is a chemical compound with the formula C7H6F3N. It is a colorless liquid with a strong, sweet odor, and is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized as a building block in the production of various specialty chemicals and as a solvent in organic synthesis. Additionally, the compound is known for its high boiling point and low melting point, making it suitable for a range of industrial applications. However, due to its potential health and environmental hazards, proper handling and disposal procedures must be followed when working with 2-Methyl-5-(trifluoromethyl)pyridine.

InChI:InChI=1/C7H6F3N/c1-5-2-3-6(4-11-5)7(8,9)10/h2-4H,1H3

Upstream product

• 109-06-8 α-picoline 
• 75-63-8 Bromotrifluoromethane 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 75-24-1 trimethylaluminum 
• 304-59-6 Rochelle's salt 
• 87-69-4 tartaric acid 

Downstream Products

• 128790-14-7 5-trifluoromethyl-pyridin-2-ylmethyl chloride 
• 1810715-04-8 methyl 2-(5-(trifluoromethyl)pyridin-2-yl)acetate 
• 205313-15-1 [1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-{3-[(E)-2-(5-trifluoromethyl-pyridin-2-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid methyl ester 

Relevant articles and documents

Preparation method of 2-methyl-5-(trifluoromethyl)pyridine

The invention discloses a preparation method of 2-methyl-5-(trifluoromethyl)pyridine. The preparation method is characterized by comprising the following steps: dissolving 2-chloro-5-trifluoromethyl pyridine in a solvent, and carrying out a reaction with a malonate under an alkaline condition to obtain 2-(5-trifluoromethyl-pyridin-2-yl)-malonate; and hydrolyzing the 2-(5-trifluoromethyl-pyridin-2-yl)-malonate in an alkaline water solution to obtain the 2-methyl-5-(trifluoromethyl)pyridine. According to the invention, the 2-methyl-5-(trifluoromethyl)pyridine is synthesized through two steps ofreactions, and the method has the advantages of short reaction steps, mild conditions and simple and convenient operation.

Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors

Perfluoroalkylation of electron-rich aromatic compounds with trifluoromethyl bromide, or long-chain perfluoroalkyl iodides, was performed in the presence of sodium dithionite or zinc-sulphur dioxide.This alkylation occurred at the ortho and para positions relative to the amino or hydroxy substitutent.Pyrroles were perfluoroalkylated regioselectively at the 2-position.This alkylation was interpreted as a radical aromatic substitution; the formation of the perfluoroalkyl radical can be induced by a single-electron transfer from sulphur dioxide radical anion to the perfluoroalkyl halide.