205322-58-3Relevant academic research and scientific papers
Catalytic asymmetric total syntheses of (R)-bgugaine and (R)-irnidine
Maddocks, Christopher J.,Clarke, Paul A.
, (2020/12/21)
An enantioselective total synthesis of (R)-bgugaine and the first enantioselective total synthesis of (R)-irnidine are reported. The key steps are the asymmetric ‘clip-cycle’ formation of the pyrrolidine ring in 94:6 e.r., which is common to both natural
Asymmetric "clip-Cycle" Synthesis of Pyrrolidines and Spiropyrrolidines
Maddocks, Christopher J.,Ermanis, Kristaps,Clarke, Paul A.
, p. 8116 - 8121 (2020/11/02)
The development of an asymmetric "clip-cycle"synthesis of 2,2- and 3,3-disubstituted pyrrolidines and spiropyrrolidines, which are increasingly important scaffolds in drug discovery programs, is reported. Cbz-protected bis-homoallylic amines were activate
New asymmetric synthesis of enantiomeric pairs of the 2-substituted pyrrolidines bgugaine and irniine
Takahata, Hiroki,Ihara, Kozue,Kubota, Minoru,Momose, Takefumi
, p. 349 - 356 (2007/10/03)
A new asymmetric route to 2-substituted pyrrolidines starting with the Sharpless asymmetric dihydroxylation (AD) of 4-pentenylphthalimide (5) followed by aminocyclization of the resultant amino alcohol is presented. The application to the asymmetric synth
