20534-70-7Relevant academic research and scientific papers
Synthesis and antitubercular activity of some 2-(4-substituted phenyl)-3-(4-substituted phenyl)-5-methylthiazolidin-4-ones
Patil, Sunila T.,Bhatt, Parloop A.
experimental part, p. 1405 - 1406 (2011/12/16)
The compounds 2-(4-substituted phenyl)-3-(4-substituted phenyl)-5-methylthiazolidin-4-ones were synthesized by condensing 4-substituted anilines with 4-substituted benzaldehydes by using ethanol as solvent. The synthesized compounds were heated with 2-mercaptopropionic acid in excess of benzene. The chemical nature of synthesized compounds have been confirmed by means of IR, NMR and mass data. The synthesized compounds were screened for antitubercular activity. The compounds were subjected to in vitro screening by the tube dilution technique employing the human virulent H37R V strain of M. tuberculosis using isoniazid as a reference standard. The results revealed that the test compounds IIa, IIc, IId, IIe, exhibits remarkable antitubercular activity against H37RV strain of Mycobacterium tuberculosis. The minimum inhibitory concentration (MIC) values were found in the range of 25 to 42 μg/mL.
β-Lactam derivatives as enzyme inhibitors: Halogenated β-lactams and related compounds
Elriati, Ali,Loose, Jutta,Mayrhofer, Roswitha,Bergmann, Hans-Joachim,Otto, Hans-Hartwig
experimental part, p. 835 - 846 (2009/09/06)
Different modifications of the imine - acyl chloride reaction were used for the synthesis of 3-mono- and 3,3-dihalogenated 1,4-diaryl substituted β-lactams. Furthermore, these β-lactams were modified by halogen substitution either at the aryl at position
Substituent cross-interaction effects on the electronic character of the C=N bridging group in substituted benzylidene anilines - Models for molecular cores of mesogenic compounds. A 13C NMR study and comparison with theoretical results
Neuvonen, Helmi,Neuvonen, Kari,Fueloep, Ferenc
, p. 3141 - 3148 (2007/10/03)
13C NMR chemical shifts δc(C=N) were measured in CDCl 3 for a wide set of mesogenic molecule model compounds, viz. the substituted benzylidene anilines P-X-C6H4CH=NC 6H4-p-Y (X = NO2, CN, CF3, F, Cl, H, Me, MeO, or NMe2; Y = NO2, CN, F, Cl, H, Me, MeO, or NMe2). The substituent dependence of δc(C=N) was used as a tool to study electronic substituent effects on the azomethine unit. The benzylidene substituents X have a reverse effect on δc(C=N): electron-withdrawing substituents cause shielding, while electron-donating ones behave oppositely, the inductive effects clearly predominating over the resonance effects. In contrast, the aniline substituents Y exert normal effects: electron-withdrawing substituents cause deshielding, while electron-donating ones cause shielding of the C=N carbon, the strengths of the inductive and resonance effects being closely similar. Additionally, the presence of a specific cross-interaction between X and Y could be verified. The electronic effects of the neighboring aromatic ring substituents systematically modify the sensitivity of the C=N group to the electronic effects of the benzylidene or aniline ring substituents. Electron-withdrawing substituents on the aniline ring decrease the sensitivity of δc(C=N) to the substitution on the benzylidine ring, while electron-donating substituents have the opposite effect. In contrast, electron-withdrawing substituents on the benzylidene ring increase the sensitivity of δc(C=N) to the substituent on the aniline ring, while electron-donating substituents act in the opposite way. These results can be rationalized in terms of the substituent-sensitive balance of the electron delocalization (mesomeric effects). The present NMR characteristics are discussed as regards the computational literature data. Valuable information has been obtained on the effects of the substituents on the molecular core of the mesogenic model compounds.
