20538-24-3

Upstream product

• 3770-50-1 2-carbethoxyindole 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 98-80-6 phenylboronic acid 
• 135055-83-3 Ethyl pyruvate 2-(2-methoxyphenyl)phenylhydrazone 
• 28719-46-2 triphenylbismuth bis(trifluoroacetate) 
• 108-86-1 bromobenzene 
• 24512-96-7 ethyl (Z)-2-azido-3-phenylacrylate 
• 100-52-7 benzaldehyde 

Downstream Products

• 142872-83-1 RX 871024 
• 343238-31-3 (1-phenyl-1H-indol-2-yl)methanol 
• 1426681-58-4 C₁₈H₁₅N₃ 
• 856337-27-4 3,3-dibromo-1-phenyl-indolin-2-one 
• 859068-29-4 3,3-dichloro-1-phenylindolin-2-one 
• 108797-02-0 2-(4,5-Dihydro-1H-imidazol-2-yl)-1-phenyl-2,3-dihydro-1H-indole 
• 108797-70-2 ethyl-2,3-dihydro-1-phenylindole-2-carboxylate 

Relevant academic research and scientific papers

Construction of N-C Axial Chirality through Atroposelective C-H Olefination of N-Arylindoles by Palladium/Amino Acid Cooperative Catalysis

Direct construction of N-C axial chirality via Pd-catalyzed atroposelective C-H olefination of N-arylindoles is reported. The crucial role of chiral amino acid as a cocatalyst in the regio- and stereocontrol has been disclosed. In this reaction, a wide range of arylindoles and functional alkenes could be well tolerated. Moreover, the practicality and synthetic value of this process were demonstrated by the divers and simple transformations of the products.

N-(piperidin-4-yl)-1H-indole-2-carboxamide derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating Urotensin-Ⅱ receptor activity related diseases containing the same as an active ingredient

The present invention relates to N-(piperidin-4-yl)-1H-indole-2-carboxamide derivatives, a preparation method thereof, and a pharmaceutical composition for preventing or treating urotensin-II receptor activity-related diseases comprising the same as activ

Efficient preparation method of 3-substitued-benzo five-membered heterocycle-2-carbonyl compound

The invention discloses an efficient compounding method of a 3-substitued-benzo five-membered heterocycle-2-carbonyl compound. According to the method, a 3-substitued-benzo five-membered heterocycle-2-alcohol compound is subjected to a halogenated oxidation reaction by a halogenating reagent to generate the corresponding 3-substitued-benzo five-membered heterocycle-2-carbonyl compound. The efficient compounding method has the advantages that raw materials are easy to get, reaction conditions are mild, and reaction selectively and yield are high.

Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives

A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggested that proton or a small electron-withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume for this kind of molecules.

Synthesis of polycyclic indolone and pyrroloindolone heterocycles via the annulation of indole- and pyrrole-2-carboxylate esters with arynes

A mild and general method for the synthesis of a variety of polycyclic indolone and pyrroloindolone heterocycles via the reaction of indole- and pyrrole-2-carboxylate esters with arynes has been developed. Georg Thieme Verlag Stuttgart.

COPPER CATALYSED PHENYLATION OF INDOLES BY TRIPHENYLBISMUTH BIS TRIFLUOROACETATE

Indoles are C(3)- or N-phenylated by triphenylbismuth bis-fluoroacetate under copper catalysis.C(3)-Phenyl derivatives are obtained with C(3)-unsubstituted indoles and N-phenyl derivatives with C(3)-substituted indoles.