20538-40-3

Upstream product

• 938-36-3 1-methyl-2-phenylpyrrolidine 
• 201230-82-2 carbon monoxide 
• 13466-43-8 3-bromopyridin-2(1H)-one 
• 52200-48-3 3-bromo-2-chloropyridine 
• 81971-38-2 3-bromo-1-methyl-1H-pyridin-2-one 
• 98-80-6 phenylboronic acid 
• 13180-21-7 1-methyl-3-phenylpyridin-2(1H)-one 

Relevant academic research and scientific papers

Asymmetric Homogeneous Hydrogenation of 2-Pyridones

An asymmetric homogeneous hydrogenation of 2(1H)-pyridones has been developed, using a ruthenium complex bearing two chiral N-heterocyclic carbene (NHC) ligands. To the best of our knowledge, the presented reaction is the first example of a homogeneous asymmetric conversion of 2-pyridones into the corresponding enantioenriched 2-piperidones.

Iron-catalyzed regioselective direct arylation at the C-3 position of N-alkyl-2-pyridone

A number of pharmaceutical compounds possess an arylated 2-pyridone moiety. The existing reports using expensive starting materials and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method for their synthesis. In this report, we demonstrate an easy-to-handle reaction condition with an iron catalyst for the exclusive generation of C-3-arylated pyridone via C-H functionalization.