2-Piperidinone, 1-methyl-3-phenyl-

Base Information

• Chemical Name: 2-Piperidinone, 1-methyl-3-phenyl-
• CAS No.: 20538-40-3
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Mol file: 20538-40-3.mol

Synonyms:

Chemical Property of 2-Piperidinone, 1-methyl-3-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Piperidinone, 1-methyl-3-phenyl-

There total 5 articles about 2-Piperidinone, 1-methyl-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-methyl-3-phenylpyridin-2(1H)-one (13180-21-7) → 1-methyl-3-phenyl-piperidin-2-one (20538-40-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 24h; under 760.051 Torr;

DOI:10.1021/jo502362k

Reference yield: 56.0%

1-methyl-2-phenylpyrrolidine (938-36-3) + carbon monoxide (201230-82-2) → 1-methyl-3-phenyl-piperidin-2-one (20538-40-3)

Guidance literature:

With dicobalt octacarbonyl; In benzene; at 200 - 220 ℃; for 72h; under 41040 Torr; Product distribution; Mechanism; other substituted nitrogen heterocyclics; also Co₂(CO)8/Ru₃(CO)12 catalyzed rearrangement reactions;

DOI:10.1021/ja00044a010

Reference yield:

3-bromopyridin-2(1H)-one (13466-43-8) → 1-methyl-3-phenyl-piperidin-2-one (20538-40-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / 1,4-dioxane / 2 h / 100 °C / Schlenk technique; Inert atmosphere

1.2: 16 h / 80 °C / Schlenk technique; Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / toluene; ethanol; water / 16 h / 80 °C / Schlenk technique; Inert atmosphere

3.1: potassium tert-butylate; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,3-bis-(1(R)-phenyl-ethyl)-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborate; hydrogen / hexane; tert-Amyl alcohol / 24 h / 25 °C / 90009 Torr / Glovebox; Schlenk technique; Autoclave

With bis-triphenylphosphine-palladium(II) chloride; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,3-bis-(1(R)-phenyl-ethyl)-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborate; potassium tert-butylate; hydrogen; sodium carbonate; In 1,4-dioxane; tert-Amyl alcohol; ethanol; hexane; water; toluene;

DOI:10.1055/s-0034-1378703

upstream raw materials:

1-methyl-2-phenylpyrrolidine

carbon monoxide

1-methyl-3-phenylpyridin-2(1H)-one

3-bromo-1-methyl-1H-pyridin-2-one