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21α,22-Dihydrostrychnidine is a naturally occurring alkaloid derived from the Strychnos nux-vomica plant, which is known for its highly toxic properties. This chemical compound is a reduced form of strychnine, another potent alkaloid found in the same plant. 21α,22-Dihydrostrychnidine is structurally similar to strychnine, with the primary difference being the presence of a double bond between carbons 21 and 22 in strychnine, which is replaced by a single bond in the dihydro form. This slight structural change can lead to variations in the compound's biological activity and toxicity. The compound has been studied for its potential applications in pharmaceutical research, particularly in the development of drugs targeting the glycine receptor, which is involved in the transmission of nerve impulses. However, due to its toxic nature, the use of 21α,22-Dihydrostrychnidine in medicine is limited, and it is primarily of interest for scientific investigation.

2054-82-2

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2054-82-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2054-82-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,5 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2054-82:
(6*2)+(5*0)+(4*5)+(3*4)+(2*8)+(1*2)=62
62 % 10 = 2
So 2054-82-2 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2O/c1-2-4-16-15(3-1)21-7-9-22-12-13-6-10-24-17-5-8-23(16)20(21)19(17)14(13)11-18(21)22/h1-4,13-14,17-20H,5-12H2/t13-,14+,17+,18+,19+,20+,21?/m1/s1

2054-82-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (4S,4aS,5aS,13aS,15aS,15bR)-2,3,4,4a,5,5a,7,8,13a,14,15,15a,15b,16-tetradecahydro4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline

1.2 Other means of identification

Product number -
Other names dihydro-strychnidine-B

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2054-82-2 SDS

2054-82-2Downstream Products

2054-82-2Relevant academic research and scientific papers

Structure-activity relationships of strychnine analogs at glycine receptors

Mohsen, Amal M. Y.,Heller, Eberhard,Holzgrabe, Ulrike,Jensen, Anders A.,Zlotos, Darius P.

, p. 1256 - 1262 (2014/10/16)

Nine strychnine derivatives including neostrychnine, strychnidine, isostrychnine, 21,22-dihydro-21-hydroxy-22-oxo-strychnine, and several hydrogenated analogs were synthesized, and their antagonistic activities at human α1 and α1β glycine receptors were evaluated. Isostrychnine has shown the best pharmacological profile exhibiting an IC 50 value of 1.6μM at α1 glycine receptors and 3.7-fold preference towards the α1 subtype. SAR Analysis indicates that the lactam moiety and the C(21) C(22) bond in strychnine are essential structural features for its high antagonistic potency at glycine receptors Copyright

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