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Strychnidine is a naturally occurring alkaloid found in the seeds of the Strychnos nux-vomica tree, which is native to Southeast Asia. It is a potent neurotoxin that acts as a competitive antagonist of the glycine receptor in the central nervous system, leading to hyperexcitation and muscle spasms. Strychnidine is highly toxic, with a lethal dose for humans estimated to be around 10-20 milligrams. Due to its dangerous properties, it is not used for any legitimate medical or industrial purposes, and its possession and use are strictly regulated or banned in many countries.

2054-81-1

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2054-81-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2054-81-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,5 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2054-81:
(6*2)+(5*0)+(4*5)+(3*4)+(2*8)+(1*1)=61
61 % 10 = 1
So 2054-81-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H24N2O/c1-2-4-16-15(3-1)21-7-9-22-12-13-6-10-24-17-5-8-23(16)20(21)19(17)14(13)11-18(21)22/h1-4,6,14,17-20H,5,7-12H2/t14-,17-,18-,19-,20-,21?/m0/s1

2054-81-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name strychnidine

1.2 Other means of identification

Product number -
Other names Strychnidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2054-81-1 SDS

2054-81-1Downstream Products

2054-81-1Relevant academic research and scientific papers

Structure-activity relationships of strychnine analogs at glycine receptors

Mohsen, Amal M. Y.,Heller, Eberhard,Holzgrabe, Ulrike,Jensen, Anders A.,Zlotos, Darius P.

, p. 1256 - 1262 (2014/10/16)

Nine strychnine derivatives including neostrychnine, strychnidine, isostrychnine, 21,22-dihydro-21-hydroxy-22-oxo-strychnine, and several hydrogenated analogs were synthesized, and their antagonistic activities at human α1 and α1β glycine receptors were evaluated. Isostrychnine has shown the best pharmacological profile exhibiting an IC 50 value of 1.6μM at α1 glycine receptors and 3.7-fold preference towards the α1 subtype. SAR Analysis indicates that the lactam moiety and the C(21) C(22) bond in strychnine are essential structural features for its high antagonistic potency at glycine receptors Copyright

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