205434-84-0

Basic information

• Product Name: 1-amino-1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]hexahydropyridinium inner salt
• CAS NO: 205434-84-0
• Molecular Weight: 337.372
• Mol File: 205434-84-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-amino-1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]hexahydropyridinium inner salt(CAS DataBase Reference)
• NIST Chemistry Reference: 1-amino-1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]hexahydropyridinium inner salt(205434-84-0)
• EPA Substance Registry System: 1-amino-1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]hexahydropyridinium inner salt(205434-84-0)

Safety Data

• Hazardous Substances Data: 205434-84-0(Hazardous Substances Data)

Upstream product

• 2213-43-6 1-Aminopiperidine 
• 86386-76-7 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole 

Relevant articles and documents

The synthesis of aminimide-containing azole antifungals

The synthesis of a series of azole antifungal compounds which incorporate the aminimide functional moiety is described. The procedure involves the reaction of an epoxide intermediate with 1,1-disubstituted hydrazines to form aminimines which are subsequently treated with acyl chlorides resulting in the desired switterionic aminimides. The aminimides were tested for in vitro antifungal activity and found to be moderately active against Candida and Cryptococcus species, but inactive versus Aspergillus.