205441-75-4

Upstream product

• 205442-01-9 3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (S)-[([(3R,4R,5S)-3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-(2E)-ylidene]-{1-[1-methoxy-meth-(Z)-ylidene]-2-oxo-propylcarbamoyl}-methyl)-carbamoyl]-((S)-2-methyl-oxiranyl)-methyl ester 
• 205442-00-8 3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester 
• 205441-99-2 C₅₅H₆₆N₄O₁₅SSi 
• 205442-06-4 C₅₅H₆₈N₄O₁₅SSi 
• 13866-57-4 (E)-methyl 4-hydroxy-3-methylbut-2-enoate 
• 205441-81-2 (E)-3-(benzyloxymethoxy)methyl-2-butenoic acid 
• 205441-80-1 (E)-4-Benzyloxymethoxy-3-methyl-but-2-enoic acid methyl ester 
• 205441-77-6 2-[(E)-2-(benzyloxymethoxy)methyl-1-propenyl]-4H-oxazol-5-one 
• 205441-83-4 N-[(E)-3-(benzyloxymethoxy)methyl-2-butenoyl]glycine 
• 205441-76-5 Methanesulfonic acid (2S,3R,4R)-3,4-bis-benzyloxy-5-[2-[(S)-hydroxy-((S)-2-methyl-oxiranyl)-methyl]-5-oxo-oxazol-(4E)-ylidene]-pyrrolidin-2-ylmethyl ester 
• 228120-05-6 3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (S)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester 
• 205441-89-0 Methanesulfonic acid (2S,3R)-3-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-2,3-dihydroxy-2-methyl-propyl ester 
• 205441-84-5 2-((E)-3-Benzyloxymethoxy-2-methyl-propenyl)-4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-4H-oxazol-5-one 
• 205441-88-9 4-[(3R,4R,5S)-3,4-Bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-2-((1R,2S)-1,2,3-trihydroxy-2-methyl-propyl)-4H-oxazol-5-one 

Relevant academic research and scientific papers

Synthetic studies of carzinophilin. Part 3: Synthetic approach toward carzinophilin and successful synthesis of 13-O-desacetyl-12,13-di-O-benzyl-4-O-methylcarzinophilin

The synthetic procedures of the title compound (2), a protected form of carzinophilin (1), were developed. While efforts toward the total synthesis of 1 failed, comparison of the 1H NMR spectra of 2 and some other related compounds with that of

A stereoselective synthesis of 4-O-methyl-13-desacetyl-12,13-di-o-benzylcarzinophilin

The title synthesis was achieved by the synthetic scheme featuring the following four key steps: i) coupling of the methyl thioimidate with the 2-oxazolin-5-one (5+6→13), ii) construction of the C17-C21 functionality by the use of Sharpless asymmetric dih