205443-26-1Relevant academic research and scientific papers
Highly efficient and enantioselective biotransformations of racemic azetidine-2-carbonitriles and their synthetic applications
Leng, Dong-Hui,Wang, De-Xiang,Pan, Jie,Huang, Zhi-Tang,Wang, Mei-Xiang
experimental part, p. 6077 - 6082 (2009/12/26)
(Chemical Equation Presented) Catalyzed by the Rhodococcus erythropolis AJ270 whole cell catalyst in neutral aqueous buffer at 30 °C, a number of racemic 1-benzylazetidine-2-carbonitriles, trans-1-benzyl-4-methylazetidine-2- carbonitrile, and 1-benzyl-2-m
Enzymatic resolution of methyl N-alkyl-azetidine-2-carboxylates by Candida antarctica lipase-mediated ammoniolysis
Starmans, Wim A. J.,Doppen, Roy G.,Thijs, Lambertus,Zwanenburg, Binne
, p. 429 - 435 (2007/10/03)
A facile method for the synthesis of optically active azetidine-2- carboxylic acid derivatives is presented Racemic N-alkylated azetidine esters are resolved by lipase from Candida antarctica in an ammoniolysis reaction, and both the S-amide and the R-ester are obtained with excellent stereoselectivity.
7-(2-Aminomethyl-1-azetidinyl)-4-oxoquinoline-3-carboxylic acids as potent antibacterial agents: Design, synthesis, and antibacterial activity
Fujita, Masahiro,Chiba, Katsumi,Tominaga, Yukio,Hino, Katsuhiko
, p. 787 - 796 (2007/10/03)
2-Aminomethyl-1-azetidinyl, -1-pyrrolidinyl, and -1-piperidinyl groups were designed as novel C-7 substituents for potential antibacterial quinolone agents. Of the three substituents, the 2-aminomethyl-1-azetidinyl group (compound 12a) was found to be the
