205444-18-4 Usage
Uses
Used in Pharmaceutical Industry:
2-CHLORO-6-TRIFLUOROMETHYL-3-(TRIMETHYLSILYL)PYRIDINE is used as a synthetic reagent for the synthesis of biologically active molecules and pharmaceutical intermediates. Its unique functional groups and high reactivity enable the development of novel compounds with potential therapeutic applications.
Used in Agrochemical Industry:
2-CHLORO-6-TRIFLUOROMETHYL-3-(TRIMETHYLSILYL)PYRIDINE is used as a synthetic reagent for the synthesis of agrochemical compounds, such as pesticides and herbicides. Its versatility and stability contribute to the development of effective and environmentally friendly agrochemical products.
Used in Organic Synthesis:
2-CHLORO-6-TRIFLUOROMETHYL-3-(TRIMETHYLSILYL)PYRIDINE is used as a substitute for highly toxic and moisture-sensitive reagents in various organic synthesis reactions. Its wide range of reactions, including nucleophilic substitution, palladium-catalyzed cross-coupling, and aromatic functionalization, make it a valuable tool for synthetic chemists.
Check Digit Verification of cas no
The CAS Registry Mumber 205444-18-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,4,4 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 205444-18:
(8*2)+(7*0)+(6*5)+(5*4)+(4*4)+(3*4)+(2*1)+(1*8)=104
104 % 10 = 4
So 205444-18-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H11ClF3NSi/c1-15(2,3)6-4-5-7(9(11,12)13)14-8(6)10/h4-5H,1-3H3
205444-18-4Relevant academic research and scientific papers
Mongin, Florence,Tognini, Antonio,Cottet, Fabrice,Schlosser, Manfred
, p. 1749 - 1752 (1998)
When treated with lithium diisopropylamide in tetrahydrofuran at -85 °C and subsequently with iodine, 2-chloro-6-(trifluoromethyl)pyridine is neatly converted into its 3-iodo derivative. The latter can be quantitatively isomerized to afford 2-chloro-4-iodo-6-(trifluoromethyl)pyridine. Either iodo compound can serve as the starting material for further manipulation in reaction sequences consisting of halogen/metal exchange and electrophilic trapping.
